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AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas 鈥� immunology, oncology, neuroscience, and eye care 鈥� and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at听. Follow @abbvie on听,听,听,听,听听补苍诲听.

AbbVie鈥檚 Biologics CMC Analytical Research and Development Group in South San Francisco has an exciting opportunity for a Senior Scientist II to join a dynamic team of scientists responsible for all aspects of CMC analytical development required to move biologic candidates from discovery into and through clinical studies.

In this lab-based role, you will utilize your knowledge of protein chemistry and expertise in chromatography and capillary electrophoresis to contribute to development of AbbVie鈥檚 growing pipeline of clinical stage biotherapeutics, which include novel bispecific and multispecific constructs, antibody-drug conjugates, and monoclonal antibodies. You will characterize and investigate attributes of biologic drug candidates to provide product and process understanding, as well as develop innovative analytical methods that provide deeper insights into protein biotherapeutics across the development spectrum from candidate liability screening to process development to clinical development.

Key Responsibilities Include:

• Independently develop state of the art capillary electrophoresis and HPLC methods to characterize biotherapeutic proteins and their associated variants and impurities.
• Characterize post-translational modifications and structure-activity relationships of products under development.
• Develop innovative approaches to solve difficult analytical challenges.
• Represent the Biologics CMC Analytical Research and Development Group as a subject matter expert on cross functional project teams.
• Develop, qualify/validate, and transfer fit-for-purpose QC release and stability methods.
• Provide technical support and oversight for QC testing occurring at internal and external GMP laboratories.
• Plan and author characterization, comparability, and quality sections of regulatory submissions (INDs/CTDs).
• Engage and influence the broader scientific community through publications and poster and oral presentations at industry conferences.

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• Bachelor鈥檚 Degree or equivalent education and 12 years of experience, Master鈥檚 Degree or equivalent education and 10 years of experience, PhD and 4 years of experience. Applicants with less experience will be observed as well; leveling will be commensurate to experience level.听
• Must possess a solid understanding of protein chemistry and biochemistry, particularly as it relates to biotherapeutic protein drug development.
• Demonstrated proficiency in developing and performing protein capillary electrophoresis, HPLC/UPLC, and other separation methods as they apply to protein characterization.
• Experience with CMC analytical development of monoclonal antibodies or related biotherapeutic proteins is desired.
• Prior example(s) of technical/scientific achievement and innovation in advanced analytics (e.g., multi-dimensional liquid chromatography, novel separation techniques) is desirable.
• Quality control and/or GMP experience is beneficial.
• Must have strong written and verbal communications skills.
• This position is a lab-based role. To be successful, candidates must enjoy and thrive in an onsite, highly collaborative lab environment and be able to manage multiple concurrent projects with a high degree of independence.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or听local law:听鈥�

• This is an on-site opportunity located in South San Francisco.听
• The compensation range described below is the range of possible base pay compensation that the Company听believes in听good faith it will pay for this role at the time听of this posting based on the job grade for this position.听Individual听compensation paid within this range will depend on many factors including geographic location, and听we听may ultimately听pay more or less than the posted range. This range may be modified in the听future.鈥� Salary: $106,500 - $202,500
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),听medical/dental/vision听insurance and 401(k) to eligible听employees.鈥�
• This job is eligible to participate in our short-term incentive听programs.听鈥�
• This job is eligible to participate in our long-term incentive听programs鈥�

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Note: No amount of pay听is considered to be听wages or compensation until such amount is earned, vested, and听determinable.听The amount and availability of any bonus,听commission, incentive, benefits, or any other form of听compensation and benefits听that are allocable to a particular employee remains in the Company's sole and听absolute听discretion unless and until paid and听may be modified at the Company鈥檚 sole and absolute discretion, consistent with听applicable law.听鈥�

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AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.鈥� Equal Opportunity Employer/Veterans/Disabled.听

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